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Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

Pathway enrichment p values were calculated in clusterProfiler with the enrichGO function with Benjamini-Hochberg adjustment and cutoff p-value of 0.05

It works by activating fat breakdown while preventing new fat formation