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By prioritizing targeted clinical trials, biomarker-based endpoints, and long-term safety monitoring, future research can bridge the current translational gap and clarify ASTs place in neuroprotective therapy

5 Hydroxocobalamin B12 and Weight Loss Currently, vitamin B12 has been linked to weight loss and energy boosts because it helps the body convert fats and proteins into energy that aids in the breakdown of carbohydrates

When taken orally, peptides are notoriously unstable and difficult to deliver to the target location, meaning it would be very unlikely that it would reach the nucleus pulposus directly

Proposed mechanisms include upregulation of growth-hormone-receptor expression in injured tissue, VEGF-driven angiogenesis, modulation of the nitric-oxide pathway in vascular endothelium, and activation of FAK-paxillin signaling