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The green light came more than two months ahead of Casgevys March 30 PDUFA date in TDT and just one month after it made history as the first approved CRISPR-based gene-editing therapy, for sickle cell disease

Cardiac mitochondria are a prominent site of injury by doxorubicin, an anthracycline, due to its high affinity for the di-anionic phospholipid cardiolipin on the inner mitochondrial membrane [98]

Therefore, and despite the observations of parasite death in some cases, we observed major discrepancies in the literature regarding the eryptosis effect of eryptosis inducing compounds

(2) Compare the binding modes and inhibitory mechanisms of the three compounds