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Whilst the intrinsic factor-mediated absorption pathway can only process approximately 1.52 micrograms of B12 at a time, passive diffusion allows absorption of about 1% of higher doses

Extracellular LPA is generated through two main routes: membrane phospholipids are converted to phosphatidic acid (PA) by phospholipase D (PLD), then to LPA by phospholipase A2 (PLA2)

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This means that if you take more than your body needs, the excess is generally excreted in your urine, which is why B12 is considered very safe, even at high doses