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Myeloid-specific GPX4-haploinsufficient mice develop a lupus-like disease spontaneously, but complete GPX4 ablation in neutrophils results in severe neutropenia without inducing a lupus-like disease

Combined therapy amplifies individual benefits and supports comprehensive cellular health

In most eukaryotes there are two major systems to detoxify reactive oxygen species, one based on the tripeptide glutathione (GSH) and the other based on the 12 kDa protein thioredoxin (Trx)

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