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212 FBXO31 enhances cisplatin-induced ferroptosis in cholangiocarcinoma cells and stem cell-like cells, and the mechanism may be related to increased GPX4 ubiquitination and proteasome degradation, which could be reversed by GPX4 overexpression

Although the HpTpx complex with Metro depicts substantial structural rearrangements in helix 1, such conformational changes are absent in HpTpx with Metro-P3

Furthermore, GCs also promote lipogenesis in the liver, which leads to an increase in the secretion of very low density lipoproteins (VLDL)

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