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When not drinking alcohol, your body releases a hormone called vasopressin (which is also known as the antidiuretic hormone (ADH)) 1 , which tells your kidneys to hold on to water and reabsorb it back into the bloodstream

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This first-pass mechanism of periportal toxicity for selected compounds, including hepatotoxicants that primarily affect centrilobular hepatocytes, could result from deficient cytoprotective capacity secondary to depletion of phase II conjugating enzymes in addition to being a consequence of a higher exposure gradient to these upstream hepatocytes