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pylori exploits a protective metabolite from the host for nutritional gain during infection

They demonstrated that T cell-derived IFN- activates the JAK/STAT1 pathway, resulting in the formation of STAT1 homodimers that inhibit SLC7A11 transcription ( + T cells, the tumor immune microenvironment (TIME) considerably affects this mechanism, possibly restricting ferroptosis in immunologically inert malignancies ( 4 Ferroptosis and cell death in tumor immunology Ferroptosis represents a unique form of regulated cell death characterized by excessive accumulation of lipid peroxides and reactive oxygen species (ROS)

This enzyme has an antioxidant role, against the oxidative transformation (oxidation) of GSH (5)

However, there are relatively few reports on the clinical application of reduced glutathione in treating diabetes-related complications