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doi: 10.1203/01.pdr.0000196370.57200.da

IGF-I is a polypeptide that belongs to the family of insulin-like growth factors similar in molecular structure to proinsulin and is a synthetic analog of insulin-like growth factor 1 (IGF-I

Activated glial cells interfere with monoaminergic neurotransmission by reducing serotonin synthesis, altering dopamine signaling, and impairing norepinephrine regulation, thereby directly contributing to mood dysregulation and anhedonia (31)