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Lactobacillus fermentum ME-3 produces another powerful antioxidant enzyme called manganese superoxide dismutase (MnSOD). MnSOD is the primary antioxidant enzyme in mitochondria which are the energy-producing sites within cells

Results Administration of exogenous melatonin alleviates allergic airways disease severity in allergen-exposed mice Given the growing evidence linking circadian disruption to increased severity of allergic asthma ( Alternaria alternata (AA) or PBS daily for four days, with or without concurrent intraperitoneal melatonin treatment using established protocols described previously ( Figure 1A )