Environmental medicine theories suggest this binding triggers immediate and severe mast cell degranulation, forcing the cells to dump massive amounts of histamine, cytokines, and leukotrienes into the bloodstream
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6b) While this would impair killing of VSMC and VEC, which could help prevent ASCVD progression, it would similarly prevent CD8 + T cells from suppressing inflammatory CD4 + T cells, APCs that promote immune activation, and plasma cells that produce inflammatory IgG 2,4