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5) Gaps in understanding ferroptosis in DN comorbidities: DN patients often present with comorbidities (e.g., hypertension, obesity, and dyslipidemia) that exacerbate renal injury, but how these comorbidities interact with ferroptosis in DN is unexplored

The existence of a direct interaction between levodopa and the outer membrane proteins of HP was suggested by one in vitro study where levodopa concentration was reduced in a time- and HP density-dependent manner when exposed to HP, and pre-incubation of levodopa with HP showed significantly reduced bacterial adhesion to gastric epithelial cells [58]

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