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In vitro studies revealed that MSCs express BDNF, NGF, and IGF-1, which could potentially mediate neurogenesis in the hippocampus [217, 218]

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Histological analysis revealed that Dihexa treatment increased neuronal cell counts and enhanced expression of synaptophysin (SYP), a presynaptic protein marker indicating synaptic density, in the hippocampus of APP/PS1 mice