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As part of the glutamate-glutamine cycle, astrocytes and oligodendrocytes take up the neurotransmitter glutamate released from neurons at synapses, metabolize it to glutamine using GLUL, and then export it back to neurons, where glutamine is converted back to glutamate using glutaminase (GLS)

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While in primates L -dopa uptake by the brain is reduced after a high protein meal [94], amino acid supplementation in PD patients treated with L -dopa has no effect on neurological parameters [95]