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Oakley, A.J., Bello, M.L., Battistoni, A., Ricci, G., Rossjohn, J., Villar, H.O., Parker, M.W

Several signaling molecules and cytokines contribute to the shift from M1 to M2 phenotype

CNS drugs, 31(7), 549-562

This model is now widely referred to as a T2D model, it mimics the natural progression of type 2 diabetes, transitioning from insulin resistance/prediabetes to overt diabetes with hypoinsulinemia within a shortened timeframe 40