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Administering these vitamins via injection bypasses gastrointestinal absorption barriersuseful for patients with pernicious anemia, post-gastrectomy states, chronic metformin or acid-suppressing therapy that impairs B12 absorption, or conditions that reduce intestinal uptake

This can be particularly challenging for children with autism, who may already have difficulty managing stress and emotional regulation

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it was studied by Novo Nordisk and later Helsinn Therapeutics, including a Phase II trial for postoperative ileus, but development was discontinued for lack of efficacy