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These results suggest that the increased energy expenditure in male Gpr146 / mice is not driven by transcriptional activation of known thermogenic programs and may involve alternative or post-transcriptional mechanisms

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Finally, the primary outcome measures (5-km time trial performance, serum TBARS) and secondary outcome measures (GPX, SOD, other blood markers, and quality of life) as well as the specific research questions described in this manuscript was made to be identical to that of the most recent version to that registered in clinicaltrials.gov