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The various glucose-modified PIC/Ms improved brain by-products owing to their multivalent interaction with GLUT1 located on the brain capillary endothelial cells (109) siRNA loaded magnetic nanoparticles have been effectively used as delivery mechanisms for targeting microglia in AD to reduce neurodegeneration (110)

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All statins are administered in active hydroxy acid forms, except simvastatin and lovastatin, which require in vivo biotransformation from their lactone prodrug forms to exert pharmacological effects (Vickers et al., 1990