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Iodine does not prevent TSH or TSab from binding to the TSH-R but inhibits both the TSH-stimulated adenyl cyclase production of cAMP and its derived actions

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At the same time, it suppresses expression of C-C chemokine ligand 2 (CCL2/MCP-1) and CCL5 (RANTES), which are important chemoattractants for monocytes and macrophages, thereby disrupting the inflammatory microenvironment that supports lesion survival, angiogenesis, and fibrosis ( In vivo , intraperitoneal administration of luteolin in autologous EMs mouse models causes clear lesion regression, with significant volumetric reduction and structural simplification of ectopic implants