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This is now possible using bisulfite conversion combined with the next-generation sequencing (BS-Seq), which enables strand-specific and single-base resolution profiling of both CG and non-CG methylation (Cokus et al., 2008

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This seeming discrepancy could be due to differences in measurement methods (e.g., MR sequences and quantification methods) and sampled brain regions, thus warrants further investigation

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