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Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis

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Treatment should be guided by a licensed medical provider and used as part of a broader plan that may include nutrition changes, physical activity, and behavioral support

A Phase 2 clinical trial studied ipamorelin for postoperative ileus (delayed bowel recovery) in patients undergoing abdominal surgery