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The rate of infusion is set to give the dose over 30 minutes to 1 hour

4 If vitamin B12 is lyophilized, such as in some forms of methylcobalamin, the medication should be refrigerated after mixing

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For instance, one study notes that people with excess weight or obesity appear to have lower vitamin B12 levels than people who have a body mass index (BMI) in the normal range ( Additional research has observed that people who voluntarily took vitamin B12 supplements gained between 2.517 fewer pounds (1.27.7 kg) over 10 years than those who did not supplement with this vitamin ( Still, such observational studies cannot confirm whether low vitamin B12 levels are what caused the weight gain, nor whether theyre what protected against low levels