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(63) demonstrated that the DIO2 Thr92Ala polymorphism substantially reduces type 2 deiodinase activity, impairs local T4-to-T3 conversion, and is associated with lower serum T3 levels in patients treated with levothyroxine

The third error relates to the copper complex using GHK-Cu that has degraded or lost its copper complexing changes the active compound delivered, so the calculated copper peptide dosing differs from the actual active dose

Statistical heterogeneity was measured using I 2 statistic and I 2 statistic with significance set at I 2 greater than 50% [11]

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