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Estabilidad y Vida Media Vida media plasmtica: Muy corta aproximadamente 5-10 minutos tras administracin parenteral en estudios farmacocinticos en roedores

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FDA staff's own briefing document, posted publicly ahead of the meeting as part of the docket, proposes that TB-500 (free base) and TB-500 acetate not be added to the list, citing incomplete physicochemical characterization, a lack of evidence of effectiveness for wound healing (including an in-vitro fibroblast study in which TB-500 reportedly did not induce wound healing), and insufficient nonclinical and clinical safety data

S., Sjberg, J., Heikinheimo, O., Btzow, R., Aaltonen, L