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Western blot analysis revealed changes in ferroptosis-related proteins in the placenta of PE patients, with increased ACSL4 expression and decreased GPX4 and SLC7A11 expressions (Fig

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Moreover, given that drug exposure is expected to be highest in the olfactory bulbs compared to other brain regions, IN chelator therapy may be particularly beneficial for disorders involving early olfactory bulb pathology or localized iron dysregulation near the nasal region ( 5.1 Mechanism of intranasal delivery Since William Frey II proposed intranasal administration in 1991 ( The transport of drug molecules from the nasal cavity to the brain involves two primary pathways: intracellular and extracellular