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A first-in-human, randomized, double-blind study of safety and pharmacokinetics in adults suggested that NYX-2925 was safe and well tolerated

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First, to identify the clusters, the deconvolved (5 iterations) and bleached corrected images were filtered using a combination of Laplacian filter (3 pixels), to enhance their contrast, and the Gaussian filter (1 pixel), to reduce the background

Pediatr Res 52 : 4649 Dani C, Giannini L, Bertini G, Pratesi S, Corsini I, Longini M, Buonocore G, Masini E, Rubaltelli FF 2007 Changes of nitric oxide, carbon monoxide and oxidative stress in term infants at birth