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The concern with chronic supratherapeutic exposure is not acute toxicity but unknown long-term effects on angiogenic and growth-factor pathways

Foundational research is available through PubMed (pubmed.ncbi.nlm.nih.gov) and the National Institutes of Healths PMC database (pmc.ncbi.nlm.nih.gov), where researchers can access peer-reviewed studies on NNMT inhibitor cellular biology and 5-Amino-1MQ specifically

10.1186/s12951-022-01407-8 9

It has been suggested that their use over many years could cause physical changes such as shrinkage of the cerebral cortex, as has been shown in chronic alcoholics, and that such changes may be only partially reversible after withdrawal