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[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Piccirillo R

Effect Pending Publication Date: 2022-07-01 View PDF0 Cites 0 Cited by Summary Abstract Description Claims Application Information AI Technical Summary This helps you quickly interpret patents by identifying the three key elements: Problems solved by technology Method used Benefits of technology Problems solved by technology However, since all polypeptide fragments are fully protected, poor solubility becomes the most difficult problem encountered in this method, and fully protected polypeptide fragments cannot be purified by high performance liquid chromatography, and impurities in the final semaglutide crude peptide There are many, and the technical requirements for separation and purification are also very high In addition, because the amino acid residues at the end of the fragment may racemize during the coupling process, the coupling sites can only be limited to the Gly and Pro sites that cannot be racemized or the sites with a relatively small risk of racemization Method used the structure of the environmentally friendly knitted fabric provided by the present invention