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Glutathione exists in almost all body cells that act as antioxidants, hydrogen donors, to free radicals to prevent oxidative stress.29,30 Oxidative stress is a trigger for PCO disease, oocyte damage, and infertility.31 A mixture of ginger and gelam honey can overcome oxidative stress conditions in diabetes mellitus patients by decreasing ROS production by increasing Glutathione levels in the blood.32 Our research shows that the administration of ginger honey supplements can significantly increase glutathione levels by 0.447ng/ml