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Therefore, mTORC1 detects the availability of glutamine in two directions: when glutamine is available, mTORC1 is activated by the production of -ketoglutarate

The ratio of transamination to -elimination depends in part on the electron-withdrawing properties (nucleofugacity) of the group attached at the -position of the amino acid substrate

C., Tsai, C

10.1001/jamapsychiatry.2017.3572 Summary Keywords amyotrophic lateral sclerosis, magnetic resonance spectroscopy, glutamate, GABA, biomarker Citation Caldwell S and Rothman DL (2021) 1 H Magnetic Resonance Spectroscopy to Understand the Biological Basis of ALS, Diagnose Patients Earlier, and Monitor Disease Progression