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Although long used in biomedical applications, interest in biopolymers as antibacterial agents has surged, with publications on their use rising by approximately 400% since 2015 ( Approximately two decades ago, antibacterial biopolymers, e.g., those with intrinsic antibacterial activity, were first proposed as alternatives to antibiotics for treating bacterial infections ( Notably, NDBs disrupt bacterial membranes instead of targeting specific metabolic pathways, a mechanism less prone to resistance development ( 2 Antibiotics and antibiotic resistance In the pre-antibiotic era, more than half of deaths were attributable to infections (Table 1)

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