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10.1016/j.cell.2017.03.022 78 LohK

In macrophages, 4-octyl itaconate, a cell-permeable derivative of endogenous itaconate, inhibits Nrf2 degradation pathway and promotes transcription of target genes, including SLC7A11, glutathione-cysteine ligase, and Gpx4, alleviating sepsis-induced acute lung injury [118]

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