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The patent gives exceedingly little information about the isolation process, stating only that a variety of relatively crude chromatographic approaches were utilized (i.e., ion-exchange and gel) followed by dialysis (i.e

These genes have varying impacts on RA onset, with the HLA-DRB1 gene being widely acknowledged as the primary susceptibility gene for RA in certain populations [28]

MRI and electrophysiological evidence of damage to the spinal cord and/or peripheral nerves