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ClinicalTrials.gov TRIUMPH-1: A Master Protocol to Investigate the Efficacy and Safety of Retatrutide (LY3437943) Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Overweight (NCT05929066)

Eyeliss (hesperidin methyl chalcone, dipeptide-2, and palmitoyl tetrapeptide-7 combination) specifically targets fluid retention dark circles through improving lymphatic drainage removing accumulated fluids, reducing capillary permeability decreasing fluid leakage into surrounding tissues, and anti-inflammatory effects minimizing puffiness-related darkness

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FDA flagged both as potentially clinically relevant signals that warrant caution