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Most people start with 100200 mg IV NAD+ once per week, combined with 2550 mg subcutaneous NAD+ injections twice weekly and 250 mg daily of oral NMN or NR

This is probably the biggest safety concern

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This may lead to a cascade of symptoms and conditions, including: Chronic inflammation is when the increased permeability can lead to systemic inflammation, which is linked to a variety of long-term health concerns, including metabolic disorders and joint pain