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Although T cells recognize tumor cells in the human body and kill them, the interaction between PD-1 on T cells and PD-L1 on tumor cells leads to T cell exhaustion 91,92,93

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Allergy management reduces chronic periorbital inflammation driving melanin production, vascular dilation, and fluid retention - users should identify and address environmental allergies through appropriate medications or avoidance, manage seasonal allergies proactively before symptoms worsen, avoid rubbing eyes despite itching creating mechanical irritation and post-inflammatory hyperpigmentation, and consider antihistamine eye drops for direct ocular symptom relief

The mean age was 47 years