In this study, it was also demonstrated that treatment with the inhibitor of cholesterol synthesis fluvastatin (Fig
For the identification of druggable targets, we considered three classes of enzymes: tier-1 targets, tier-2 targets, and other enzymes. Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability
3e, Table 1)
Water, butylene glycol (1,3, butanediol), tocofersolan, hyaluronic acid, ethanol, caprylyl glycol, medium chain triglycerides, copper tripeptide-1 (GHK-Cu), highly purified phospholipids, natural mixed tocopherols, Psoralea corylifolia seed/leaf extract (Bakuchiol), Tetrahexyldecyl ascorbate, lavender essential oil, estriol, estradiol