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Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

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At this end, proper labeling of polymeric nanocarriers is required to enable their visualization via various imaging modalities

Dado que la va opera dentro de la clula, influye en la remodelacin estructural en lugar de en la retencin superficial de lquidos o en efectos transitorios