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For the dietary intervention studies (Table 2, n = 6 publications representing 5 independent trials), data extraction included study design and quality indicators, sample characteristics and diagnostic criteria, details of the intervention such as diet type, duration, and adherence monitoring, outcome measures including opioid peptide levels and behavioral assessments, and reported results along with effect sizes

"Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+"

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