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-Endorphin, in turn, activates -opioid (mu-opioid) receptors on the GABA interneurons and inhibits the tonic release of GABA

Gentle mixing by rolling the vial between the hands may be appropriate if settling has occurred, but aggressive agitation should be avoided

Antioxidant supplementation can remove excess reactive oxygen species, reduce inflammation, and stabilize the oxidative-reductive environment, thereby improving skeletal muscle blood flow and oxygen utilization capacity, the researchers wrote in the study summary