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While intermediate metabolites associated with TCA cycle (Tricarboxylic Acid Cycle) such as fumarate, succinate, and malate were not significantly different between the groups, we suggest a decrease in mitochondrial activity may result in lower ATP generation as reported in other inflammatory conditions (65, 66)

Neuropsychiatric symptoms from vitamin B12 deficiency generally improve gradually with treatment, with noticeable changes beginning around 3 months after initiation and continuing for up to a year