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They chose to synthesize new molecules derived from N (1alkyl3cyano1 H indol5yl) to repair the missing hydrogen bond interaction between the 3cyano residue and Asn768 of XO, shortening its distance, which through molecular docking and molecular dynamics studies proved its presence

In another study, GBs protective effect on melanocytes was shown to be dependent on activation of the Nrf-ARE pathway and downstream antioxidant genes, including NQO-1, SOD2 and haem oxygenase-1 [107]

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[DOI] [PubMed] [Google Scholar] 128.Zhang T., Liu T., Shao J., Sheng C., Hong Y., Ying W., Xia W