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The study revealed that early intervention with bevacizumab on VEGF function improved BBB integrity, cerebrovascular response, and long-term memory in mice (Zhang and Zhang 2024)

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This is related to an imbalance in reactive oxygen species (ROS) homeostasis, which is mainly regulated by mitochondrial function, thereby suggesting a link between oxidative impairment in mitochondrial function in response to chronic stress and mood instability (Lushchak et al., 2023)

LRP1 exerts significant effects on neuronal function and early development by modulating synaptic generation and neuronal activity