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When repeated administration is expected to be relevant for the future therapeutic use of the compound, the study may subsequently progress to a Multiple Ascending Dose (MAD) phase

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As will be discussed, one mechanism which may connect thiol-metal binding to oxidative stress-mediated toxicity is specific of Hg, the cysteinyl-glycine bound form of which is able to deplete glutathione reservoirs by a catalytic process [34]

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