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By addressing the root causes of cellular aging, Epitalon offers a promising strategy to not only extend lifespan but also enhance the quality of life as we age

Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose

Knockdown was maintained over the LPS time-course

Mechanism of Action# Preclinical mechanism -- The following description is based on cell culture and animal studies