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The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism

Abbreviations Kla: Lysine lactylation LDH: Lactate dehydrogenase MCTs: Monocarboxylate transporters PTMs: Post-translational modifications HIF-1: Hypoxia-inducible factor 1-alpha TAMs: Tumor-associated macrophages EMT: Epithelial-mesenchymal transition TME: The tumor microenvironment CAFs: Cancer-associated fibroblasts ICIs: Immune checkpoint inhibitors ACSS2: Acetyl-CoA synthetase 2 GNAT: GCN5-related N-acetyltransferase CBP: CREB-binding protein AARS1: Alanyl-tRNA synthetase 1 TEAD1: TEA-domain-transcription-factor-1 cGAS: Cyclic-GMP-AMP synthase H3K18la: H3 lysine-18 lactylation sEVs: Small extracellular vesicles CCSCs: Colorectal cancer stem cells GSCs: Glioma stem cells ECM: Extracellular matrix EC: Esophageal cancer ESCC: Esophageal squamous cell carcinoma GC: Gastric cancer CRC: Colorectal cancer HCC: Hepatocellular carcinoma PC: Pancreatic cancer PDAC: Pancreatic ductal adenocarcinoma NSCLC: Nonsmall cell lung cancer MM: Multiple myeloma RCC: Renal cell carcinoma References Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, et al

As a licensed naturopathic physician, she utilizes her prescriptive authority, holds an active DEA license, and aligns her educational frameworks with leading global guidelines, including ESHRE and The Menopause Society