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It is not clear why one person may smoke two packs per day for 30 years and never develop COPD symptoms and another person may smoke only half a pack per day for 10 years and still develop significant COPD symptoms

And yet, the committee dutifully cleansed the men by Smooking them and Lett them pass, trusting in the purifying power of the smoke despite smallpox prevailing in Boston.[10] Since taking command at Cambridge in July 1775, General Washington had guarded against the ever-present threat that smallpox posed to the army, its potential for destruction never far from his mind

Substance Abuse and Mental Health Services Administration

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