The five stars of the right side make up the Southern Cross constellation.
In addition to its harmful constituents, cannabis contains cannabinoids, such as cannabidiol (CBD) and THC, which have demonstrated anti-inflammatory, bronchodilatory, and even antineoplastic properties in preclinical models (14,15)
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Figure 1 Materials and methods A search of scientific literature was conducted using the PubMed database ( The following Medical Subject Headings (MeSH) terms were used: e-cigarettes AND flavor AND nicotine AND e-liquid AND cytotoxicity AND cellular damage and health AND adolescent AND young people. We included publications from 2020 to 2025 because fourth-generation electronic cigarettes appeared on the market in 2020 ( in vitro studies, in silico models, and studies using cannabis cigarettes or tobacco flavors, hookahs, nicotine pouches, and waterpipes
