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Despite that, government agencies often seem to prefer that companies carry out animal tests to assess the toxicity or efficacy of products such as industrial chemicals, pesticides, medical devices and medicines

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The treatment is often a root canal procedure, which removes the dead tissue from inside the tooth, while keeping the tooth intact

Macrophages regulate epithelial and stromal cell function by secreting enzymes and inflammatory factors that act directly and indirectly on airway structural cells, such as IL-1, TNF-, IL-8, monocyte chemoattractant protein-1(MCP-1), reactive oxygen species (ROS) and MMPs, directly involved in the process of airway remodelling 60,61