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However, when the effect of oxidation is greater than the antioxidant effect, the infiltration of inflammatory cells occurs, the secretion of various proteases and cytokines increases, and a large amount of oxidative intermediate products are generated, which in turn cause a series of physiological and pathological changes ( free radicals, and excessive O accumulation induces endothelial cell dysfunction through multiple pathways
Though, it has been over four years since passing of the Ordinance but we cannot clearly say that the battle is over yet as since the passing of the ordinance it has not been fully implemented in full force
By targeting the gut microbiome, these therapies offer a novel and potentially effective strategy for mitigating the risks and progression of hyperuricemia and gout, thereby contributing to a more holistic and personalized treatment approach in clinical practice